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Perspectives in melanoma: meeting report from the "Melanoma Bridge" (December 5th-7th, 2019, Naples, Italy).

J Transl Med · 2020 · PMC7487701 · PMID 32894202

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showed a trendno p-value reported
A > 50% increase in ctDNA, or detectable/increasing ctDNA at first follow-up were significantly associated with worse OS while patients with high TMB showed a trend towards prolonged survival.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.