Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice.

Acta Neuropathol Commun · 2020 · PMC7487850 · PMID 32891185

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.0653

boldest claim

The sentences

highly significantp < 0.0001actually significant

In Tg mice treated with LM11A-31, no difference in spine density between Tg and Ntg mice could be detected in either apical or basal spines, consistent with a highly significant drug effect (p < 0.0001).

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a strong trendp = 0.0653so close (0.05 < p ≤ 0.1)

In the < 50 and ~ 68/64 kDa ranges signal was significantly decreased by LM11A-31 treatment (each p < 0.0001), and in the > 75 kDa range there was a strong trend towards a decrease (p = 0.0653).

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