SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1α-LIPIN 1 pathway and increasing CD36 through Nrf2.

Cell Commun Signal · 2020 · PMC7488148 · PMID 32912335

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did not reach statistical significanceno p-value reported

Incubation of cells with palmitate led to a significant increase in triglyceride accumulation and this was exacerbated in cells transfected with siRNA against SIRT3 , although differences did not reach statistical significance.

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