However, after stratification of the samples into ALS patients and controls, the contributions of age and sex on D-loop methylation levels were highly significant in control subjects, while they were not evident in ALS patients.
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Reduced mitochondrial D-loop methylation levels in sporadic amyotrophic lateral sclerosis.
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The sentences
The mtDNA copy number showed a trend to be higher in ALS patients compared to control subjects, although this was not statistically significant (147.04 ± 57.22 vs. 127.75 ± 57.27, p = 0.07, 95% CI − 40.75 to 2.16) (Fig. 4 b).