Neutropenia and survival outcomes in metastatic colorectal cancer patients treated with trifluridine/tipiracil in the RECOURSE and J003 trials.

Median OS tended to be longer in the high versus low FTD AUC groups [9.2 versus 7.2 months, respectively (HR, 0.72; 95% CI, 0.46–1.11)], but did not reach statistical significance ( Figure 1A ; Table 1 ; supplementary Table S2 , available at Annals of Oncology online).There was no significant difference in median PFS in the high versus low FTD AUC groups (HR, 0.82; 95% CI, 0.57–1.18) ( Figure 1C ; Table 1 ; supplementary Table S2 , available at Annals of Oncology online).

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