Altered Gut Microbiota Composition Is Associated With Back Pain in Overweight and Obese Individuals.

The alpha diversity (i.e., the diversity of the gut microbiota within an individual) was higher in people who experienced back pain in the past month when assessed with the Chao1 index ( Figure 1A , P = 0.0018) and with borderline significance when assessed with the Shannon index ( Figure 1B , P = 0.05).

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In the group with back pain, Roseburia abundance tended to negatively correlate with BMI but this did not reach statistical significance (rho = −0.44, P = 0.1) ( Figure 2C ) whereas in the group without back pain, Roseburia abundance was positively correlated with BMI (rho = 0.51, P = 0.016) ( Figure 2D ).

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