In vitro long-term repeated exposure and exposure switching of a novel tobacco vapor product in a human organotypic culture of bronchial epithelial cells.

J Appl Toxicol · 2020 · PMC7496418 · PMID 32319113

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an increasing trendno p-value reported

However, a significant increase in AK release was observed after day 22, and an increasing trend continued until day 40.

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did not reach statistical significanceno p-value reported

Increased MMP‐9 secretion oscillated after day 27, and even after switching, increased MMP‐9 secretion was observed at day 27 in the NTV switch group and cessation of the exposure group although it did not reach statistical significance.

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