Interaction of FGF9 with FGFR3-IIIb/IIIc, a putative driver of growth and aggressive behaviour of hepatocellular carcinoma.

Liver Int · 2020 · PMC7496895 · PMID 32378800

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These findings were supported by a clear trend to an infiltrative growth and a higher probability of recurrence in HCC cases when overexpressing FGF9 (Figure 3C ) as well as by reports on models of various cancer entities. 19 , 21 , 24 , 25 To conclude, FGF9 may be an important driver of the aggressive phenotype by enhancing growth and invasiveness of HCC cells.

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