BRAF^V600E drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation.

Nevertheless, we observed a strong trend for higher phosphorylation of ERK and FOS and, although to a lesser extent, increased FOS and DUSP6 expression in the triple-mutant organoids under steady-state conditions (Supplementary Fig.

also in 5,725 other papers

This is in line with a highly significant correlation of the BRAF V600E -expressing COL organoids with gene expression profiles from human sessile-serrated adenoma (SSA) patients (Supplementary Fig.

also in 132,142 other papers