significant at the trend levelp = 0.054
When performing the same PLS analyses based on MD in each of the five brain regions ( Figure 2 , second row), only component 1 was significantly related to PTA (MD COMP1 : r = 0.59, p = 0.015), the second component was only significant at the trend level (MD COMP2 : r = 0.45, p = 0.054), and the third component was not significant (MD COMP3 : r = 0.09, p = 0.381).