Assessing the requirements of prenatal UBE3A expression for rescue of behavioral phenotypes in a mouse model for Angelman syndrome.

Analysis of these mice showed a tendency of decreased performance on all tests, but the effects were small and did not reach statistical significance.

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For the Nestin-Cre experiments, a highly significant effect of genotype and highly significant interaction between presence and absence of Cre versus presence of absence of Ube3a mLSL was observed for the nest building task, the marble burying test, and forced swim test (all p < 0.005).

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