The most prominent response to 3R4F CS in both studies was an increase in the levels of the metalloproteinase MMP-1, the protease inhibitor TIMP-1, and the interleukin CXCL-8; the increase in CXCL-8 levels, however, did not reach statistical significance in study #2.
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Comparing the preclinical risk profile of inhalable candidate and potential candidate modified risk tobacco products: A bridging use case.
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