The Phenomenon of Clopidogrel High On-Treatment Platelet Reactivity in Ischemic Stroke Subjects: A Comprehensive Review.

[ 12 ] demonstrated a highly significant association between the coadministation of proton pump inhibitors (not specified) and clopidogrel resistance in subjects vs. the achievement of a response ( p < 0.001).

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[ 17 ] reported a trend toward a higher frequency of clopidogrel resistance in individuals with the P2RY12 H2 haplotype compared with those with the H1 haplotype, but this result did not reach statistical significance.

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[ 47 ] concluded that the antiplatelet effect of clopidogrel in ischemic stroke patients is much better in smokers and showed a statistical trend for a reduced risk of recurrent vascular events with clopidorel than with aspirin [ 47 ].

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