Barely Significant
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Temporal trend of disease recognition, treatment paradigm, and clinical outcomes of Crohn disease in Thailand from 2000 through 2017: Is early use of thiopurines beneficial?

Medicine (Baltimore) · 2020 · PMC7505316 · PMID 32957358

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a significant trendno p-value reported
[ 14 , 20 , 31 , 35 , 40 ] Interestingly, there was a significant trend toward early initiation of immunomodulators and biologics in the later study period.

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