In the case of rats treated with celastrol at the dose of 2.5 μg/g/day there is a tendency toward a decrease in the number of osteoblasts that did not reach statistical significance ( p = 0.02 vs. untreated AIA rats).
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Celastrol Efficacy by Oral Administration in the Adjuvant-Induced Arthritis Model.
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0.0200
0.0200