Drug interactions with apixaban: A systematic review of the literature and an analysis of VigiBase, the World Health Organization database of spontaneous safety reports.

31 Administration of tacrolimus led to a 13% and a 22% decrease in the Cmax and the AUC of apixaban, respectively, but it did not reach statistical significance. 31 Finally, administration of clarithromycin to healthy volunteers led to an increase in the Cmax and the AUC of 30% and 60%, respectively, compared to administration of apixaban alone. 32 Phase III studies Flaker et al analyzed the influence of amiodarone on the outcomes of the ARISTOTLE trial, which compared apixaban and warfarin for the prevention of stroke or systemic embolism in AF patients. 33 Statistical analysis performed in their study only compared apixaban versus warfarin.

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