A cell-type deconvolution meta-analysis of whole blood EWAS reveals lineage-specific smoking-associated DNA methylation changes.

In line with this and the results in the TZH cohort, the 60 hypomethylated gsSMK-CpGs exhibited a clear trend toward hypomethylation in smokers in the Liu, Hannum, and Tsaprouni cohorts, which was only consistent and much stronger in myeloid cells (Fig. 2b–d ).

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These analyses confirmed that the 53 gsSMK-CpGs exhibited highly significant trends toward hypomethylation in smokers in both lineages, but more strongly so in myeloid cells (Fig. 1e, f ).

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