Glutaredoxin deficiency promotes activation of the transforming growth factor beta pathway in airway epithelial cells, in association with fibrotic airway remodeling.

Statistically significant increases in eosinophil percentages, and decreases in macrophage percentages occurred in WT or Glrx -/- mice exposed to HDM, compared to respective saline controls, while the proportion of neutrophils trended toward increases but did not reach statistical significance and lymphocyte numbers accounted for low percentages (<1%) not visible in the schematic ( Fig. 1 B, right panel).

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