Barely Significant
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Germline and somatic albinism variants in amelanotic/hypomelanotic melanoma: Increased carriage of TYR and OCA2 variants.

PLoS One · 2020 · PMC7510969 · PMID 32966289

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hedged sentence
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closest p · 0.8× alpha
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boldest claim

The sentences

nominally significantP=0.04actually significant
and X2 P=0.02 respectively).” “However, analyzing each variant separately revealed that the p.V443I variant occurred at higher frequency in AHM cases (4.44%) compared to PM cases (1.57%), BNMS controls (0.84%), or the MGRB (1.09%) (combined control comparison X2 P=.01), with comparison of any case nominally significant (X2 unadjusted P=0.04).” “Most significantly, the rs7174027*A SNP flanking the OCA2 gene promoter region/transcription start site was absent in AHM patients, compared to a frequency of 7.1% in the PM group (X2 unadjusted P=0.0005) and 9.43% frequency in the BNMS control group (X2 unadjusted P=8x10-5).” Supplementary materials have track changes and highlight marks that need to be removed.

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