Differential gene expression of tumor-infiltrating CD8⁺ T cells in advanced versus early-stage colorectal cancer and identification of a gene signature of poor prognosis.

Additionally, a trend toward reduced levels of CD3 + CD8 + T cell infiltrate was seen in patients with high ppCD8sig score, compared with those with low score; it did not reach statistical significance possibly due to small sample numbers ( figure 6B ).

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