Effects of omecamtiv mecarbil on calcium-transients and contractility in a translational canine myocyte model.

Pharmacol Res Perspect · 2020 · PMC7512116 · PMID 32969560

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did not reach statistical significanceno p-value reported

On the other hand, the effects on CT did not reach statistical significance until 3 μmol\L, a 30‐fold higher concentration compared with that for the on‐target effects, strongly suggesting that OM affected CT at 3 μmol\L via an off‐target mechanism.

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