Prognostic value of perineural invasion in prostate needle biopsies: a population-based study of patients treated by radical prostatectomy.

Loeb et al had earlier conducted a similar study involving 1256 subjects where multivariable adjusted PNI failed to reach statistical significance as an independent predictor of biochemical recurrence. 16 This study has been used as an argument against a prognostic value of PNI in biopsy; however, it should be noted that non-significance does not imply support for the null hypothesis. 18 Interestingly, the point estimate for the prognostic value of PNI in the study of Loeb et al was slightly higher than reported by DeLancey et al , so rather than showing no effect they, in fact, presented weak evidence in support of such an effect.

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