Demystifying the Molecular Basis of Pyrazoloquinolinones Recognition at the Extracellular α1+/β3- Interface of the GABA<sub>A</sub> Receptor by Molecular Modeling.

A continuous SAR is described by a smooth activity hypersurface, where a clear trend in experimental activity could be detected upon systematic chemical changes, whereas a discontinuous SAR, in contrast, is depicted by a rugged landscape where slight structural modifications lead to drastic potency differences ( Cruz-Monteagudo et al., 2014 ; Siebert et al., 2018b ).

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