Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs.

In total, 7/34 CpGs identified in the discovery cohort were nominally significant ( P < 0.05 and same direction of effect as the ARIC cohort results) (Additional file 4 : Table S3), and the effect sizes from the ARIC results and the validation meta-analysis were largely correlated ( R 2 = 0.36) (Fig. 2 ).

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