Differential mirror neuron system (MNS) activation during action observation with and without social-emotional components in autism: a meta-analysis of neuroimaging studies.

Egger’s tests remained non-significant for the right inferior frontal gyrus pars orbitalis ( p = 0.428), left supplementary motor area ( p = 0.182), and left precentral gyrus ( p = 0.551), approached significance for the left inferior parietal lobule ( p = 0.080), and reached statistical significance for the right amygdala ( p = 0.024).

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Additionally, with the exception of right postcentral gyrus and left cerebellum crus I, our findings remained significant when mean age and mean IQ were included as covariates. During the observation of stimuli containing social-emotional components, highly significant hyperactivation of the MNS in the ASD individuals was found in the right inferior frontal gyrus (orbital part).

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