[ 31 ] A highly significant increase in bile duct diameter and bile duct pressure was demonstrated after cholecystectomy which accounts for subsequent chronic inflammation.
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Risk of primary liver cancer associated with gallstones and cholecystectomy: A competing risks analysis.
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A clear trend based on gallbladder status was observed, where age- and sex- standardized incidence of PLC increased from 3.48 per 10,000 person-years to 9.43 per 10,000 person-years and 23.41 per 10,000 person-years in the normal group, GSD group and cholecystectomy group, respectively. 3.3 Association between gallbladder disease and PLC risk Table 2 showed the crude and adjusted HRs (95% CI) of new-onset PLC according to gallbladder status using Cox proportional hazards models.