APPA (apocynin and paeonol) modulates pathological aspects of human neutrophil function, without supressing antimicrobial ability, and inhibits TNFα expression and signalling.

2001 ) levels of apoptosis in APPA-treated cells at 20 h were slightly increased above untreated (UT) control cells and while this effect was dose dependent, these effects did not reach statistical significance (Fig. 1 a).

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