Local complement activation is associated with primary graft dysfunction after lung transplantation.

There was a difference between subjects with grade 2 or 3 PGD versus those with grade 0 or 1 PGD, but this did not reach statistical significance ( P = 0.073 for sC5b-9, Supplemental Figure 2B and P = 0.052 for sC4d, Supplemental Figure 2C ).

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Although we noted no differences in the absolute levels of factor B among those subjects who developed PGD as compared with those who did not develop PGD ( Supplemental Figure 4A ), the median levels of Ba were significantly elevated in these subjects ( Figure 4F and Table 3 ), and the levels of factor D demonstrated a trend toward significance ( Supplemental Figure 4B and Table 3 ).

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