Combination of peroxisome proliferator-activated receptor gamma and retinoid X receptor agonists induces sodium/iodide symporter expression and inhibits cell growth of human thyroid cancer cells.

To explore the role of NIS, PPARγ, and RXR in the clinic, we analyzed the RNA sequencing data from the TCGA data set and found that the gene expression levels of NIS, PPARγ, and RXR in thyroid tumor samples were lower than those in nontumor tissues, though the difference in RXR expression did not reach statistical significance (Fig. 1 A).

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