Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D.

We detected nominally significant enrichment for islet eQTLs for variants associated with continuous glycemic traits (normalized enrichment score (NES) = 1.27; P = 3.7 × 10 −3 ; Supplementary Fig. 9 and Supplementary Data 14 ): of all the tissues considered, islets generated the most significant enrichment for this phenotype.

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