Pharmacokinetic, pharmacodynamic, and neurochemical investigations of lamotrigine-pentylenetetrazole kindled mice to ascertain it as a reliable model for clinical drug-resistant epilepsy.

Animal Model Exp Med · 2020 · PMC7529331 · PMID 33024946

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did not reach statistical significanceP > .05actually significant

3 RESULTS 3.1 Kindling development The mean seizure severity score of the vehicle vs lamotrigine kindling groups (n = 41) did not reach statistical significance ( P > .05) throughout the kindling (Figure 2 ).

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