Microbiological and host-derived biomarker evaluation following non-surgical periodontal therapy with short-term administration of systemic antimicrobials: secondary outcomes of an RCT.

denticola at 6 months had in both antimicrobial-groups significantly less deep sites than placebo, while at those positive at 12 months showed a borderline significance ( p = 0.05) for the 3-day antimicrobial-group (Table 2 ).

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Nonetheless, these reductions did not reach statistical significance except for MMP-8, that was statistically significantly reduced compared to baseline in the 7-day antimicrobial-group; however, MMP-8 intergroup comparisons revealed no significant differences between the three groups at 12 months.

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