A minimal physiologically based pharmacokinetic model to characterize colon TNF suppression and treatment effects of an anti-TNF monoclonal antibody in a mouse inflammatory bowel disease model.

MAbs · 2020 · PMC7531524 · PMID 32967523

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showed a trendno p-value reported

Results from the isotype control treated IBD mice group (G2) also showed a trend of reduction in colon TNF concentrations with natural healing of disease.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.