Barely Significant
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Pharmacological inhibition of mTORC1 increases CCKBR-specific tumor uptake of radiolabeled minigastrin analogue [<sup>177</sup>Lu]Lu-PP-F11N.

Theranostics · 2020 · PMC7532663 · PMID 33042258

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did not reach statistical significanceno p-value reported
Enhanced uptake of [ 177 Lu]Lu-PP-F11N in RAD001-treated CCKBR tumors Biodistribution analysis in A431/CCKBR tumor-bearing mice demonstrates significant increase ( P =0.0057) in the tumor uptake of [ 177 Lu]Lu-PP-F11N in RAD001-treated animals with a ratio [RAD001/Control] of 1.79, whereas metformin treatment increased [ 177 Lu]Lu-PP-F11N uptake only moderately with a ratio [Metformin/Control] of 1.14 and did not reach statistical significance (Figure 5 A).

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