As shown in Table 4 and Figure 3 , for patients with PRs, the log-rank test showed that patients with a lower CR MD had a significant poor OS ( P = 0.04) than the patients with higher CR MD, and a borderline significant difference in OS and PFS was found for post MD ( P = 0.080 and 0.070, respectively).
We also evaluated the combined effect of post MK and post MD on survival; we found that the patients with post MK ≥ 0.80 and post MD < 1.66 mm 2 /s × 10 −3 (group 2) and other parameters (group 3) had approximately 5 and 3 times higher risk of OS compared with the patients with post MK < 0.80 and post MD ≥ 1.66 mm 2 /s × 10 −3 (group 1), although the association did not reach statistical significance for patients in group 3.