Barely Significant
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Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin - piperine nutraceutical system with improved enzyme inhibition properties.

J Enzyme Inhib Med Chem · 2020 · PMC7534320 · PMID 32967477

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quite significantno p-value reported
Accordingly, directly form NMR data one can postulate quite significant piperine interaction with other components in this particular case.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.