It is notable that when the concentration was less than or equal to 10 μM, 9za showed a trend of dose-dependent cell cycle arrest in G 0 /G 1 phase.
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A novel dual MEK/PDK1 inhibitor 9za retards the cell cycle at G<sub>0</sub>/G<sub>1</sub> phase and induces mitochondrial apoptosis in non-small cell lung cancer cells.
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