The role of cyclin D1 and Ki-67 in the development and prognostication of thin melanoma.

Contrary to our findings, these authors found an increased cyclin D1 expression in melanoma in situ compared to invasive melanoma, which could be explained by the higher number of melanomas of more than 1 mm Breslow thickness in this study, as the latter tumours showed a trend towards decreased cyclin D1 expression. 28 The proto‐oncogenic role of cyclin D1 has been characterised in various studies. 16 , 17 , 18 , 19 We propose that our immunohistochemical finding of an increased cyclin D1 expression in thin invasive melanoma also suggests a potential role of cyclin D1 during the process of invasion in the stepwise evolution of melanoma, as extensively described by Shain et al . 28 , 29 Alongside cyclin D1, genetic alterations leading to acquisition of invasive behaviour have been comprehensively investigated.

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