Molecular characterisation of TP53 mutated squamous cell carcinomas of the lung to identify putative targets for therapy.

Performing the same analysis in patients with TP53 mutated tumours all receiving adjuvant chemotherapy (n = 19), there is a borderline significance toward better prognosis for patients with higher expression of the gene. 3.4 Target gene search within specific gene expression subtypes The presence of TP53 mutations is one possible way of identifying subgroups for target gene search.

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The other top genes, SNRPD1 , EPCAM and CGREF1 , all showed a trend toward a higher risk of relapse with higher expression of the gene.

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