<i>PTPRG</i> is an ischemia risk locus essential for HCO₃^--dependent regulation of endothelial function and tissue perfusion.

The carriers of these most severe loss-of-function variants had dramatically increased risk (~7 fold) of cerebral infarction whereas the risk of acute myocardial infarction showed a tendency toward elevation that did not reach statistical significance ( Figure 7B ).

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