nominally significantp < 0.05
Eight of these 59 SNPs showed nominally significant associations with hearing difficulty in the UK Biobank (p < 0.05; S8 Table ), including both loci that reached genome-wide significance in the largest previous GWAS of ARHI[ 4 ]: rs4932196, 54 kb 3' of ISG20 (p = 2.6x10 -5 in the UK Biobank); and rs5750477, in an intron of TRIOBP (p = 1.3x10 -6 ).