Template-Directed Nonenzymatic Primer Extension Using 2-Methylimidazole-Activated Morpholino Derivatives of Guanosine and Cytidine.

However, there are clearly significant structural differences between the relatively rigid chair conformation of the morpholine ring, compared with the flexible five-membered sugar ring of the 3′-amino or ribonucleotide sugars, and these structural differences are also likely to affect the observed rates of primer extension reactions.

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