A novel biosafety level 2 compliant tuberculosis infection model using a ΔleuDΔpanCD double auxotroph of Mycobacterium tuberculosis H37Rv and Galleria mellonella.

Virulence · 2020 · PMC7550006 · PMID 32530737

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When treated with a ten-fold higher dose of ETH, MOX or PZA, a significant reduction in SAMTB lux bioluminescence was observed for MOX (x10) at all timepoints (with P < 0.0001 by 96 h post-infection); while ETH (x10) showed a trend in the reduction of SAMTB lux bioluminescence, with significant reduction at 96 h post-treatment (p < 0.05) when compared to the control ( Figure 9 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

A novel biosafety level 2 compliant tuberculosis infection model using a Δ&lt;i&gt;leuD&lt;/i&gt;Δ&lt;i&gt;panCD&lt;/i&gt; double auxotroph of &lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt; H37Rv and &lt;i&gt;Galleria mellonella&lt;/i&gt;.

The sentences

A novel biosafety level 2 compliant tuberculosis infection model using a Δ<i>leuD</i>Δ<i>panCD</i> double auxotroph of <i>Mycobacterium tuberculosis</i> H37Rv and <i>Galleria mellonella</i>.