Cannabinoid CB₁ Receptors in the Intestinal Epithelium Are Required for Acute Western-Diet Preferences in Mice.

Control IntCB 1 +/+ mice displayed robust preferences for WD when compared to SD, an effect largely absent in IntCB 1 −/− mice by 3 h ( Figure 5 a, from 92.8 ± 2.8% total kcals from WD in IntCB 1 +/+ mice compared to 46.5 ± 12.5% in IntCB 1 −/− mice; p = 0.029), and approaching significance during the 3–6 h interval ( Figure 5 b, from 96.2 ± 3.8% total kcals from WD in IntCB 1 +/+ mice compared to 46.9 ± 16.5% in IntCB 1 −/− mice; p = 0.06).

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Moreover, vehicle-treated mice displayed larger meal sizes of WD versus SD by 3 h ( Figure 1 i, p = 0.028), an effect that failed to reach significance during the 3–6 h interval ( Figure 1 j, p = 0.359), the 6–12 h interval ( Figure 1 k, p = 0.42), and the 12–24 h interval after initiation of the preference test ( Figure 1 l, p = 0.396).

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