PPARGC1A Gene Promoter Methylation as a Biomarker of Insulin Secretion and Sensitivity in Response to Glucose Challenges.

We only found a nominal positive association between the methylation levels of the CpG site -783 (measured by pyrosequencing) with the Matsuda-ISICOMP index (rho = 0.31; p = 0.02) ( Figure 3 ) with a near-significant association with ODI (rho = 0.27; p = 0.05).

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