Impact of Patient Characteristics on Treatment Outcomes in Symptomatic Venous Thromboembolism: Results of HOKUSAI-VTE Randomized Trial Analysis.

A similar relationship was seen in a pooled analysis of the RE-COVER studies, with the efficacy of dabigatran compared with warfarin being higher in older patients and lower in younger patients, 11 although this did not reach statistical significance, and no relationship was reported in published subgroup analysis of the same studies. 3 Based on a published subgroup analysis of patients older and younger than 75 years of age, the EINSTEIN studies also reported a relationship between events and age in the usual-care arm, although the EINSTEIN results seem less pronounced than that which may be expected. 5 12 A similar effect on treatment outcomes in the HOKUSAI-VTE trial was found with respect to creatinine clearance, but creatinine clearance is strongly related to age.

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