We next confirmed these results at the protein level; on Th1 cells, PlexinD1 neutralization significantly increased the secretion of IFNγ and showed a trend towards a higher production of this cytokine after restimulation with PMA/ionomycin.
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Semaphorin4A-Plexin D1 Axis Induces Th2 and Th17 While Represses Th1 Skewing in an Autocrine Manner.
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