The Phosphodiesterase Type 5 Inhibitor Sildenafil Improves DNA Stability and Redox Homeostasis in Systemic Sclerosis Fibroblasts Exposed to Reactive Oxygen Species.

A further analysis of cell proliferation at T0 and T24, on both types of fibroblasts, highlighted a generalized reduction of cell proliferation following H 2 O 2 exposure ( p < 0.05 and p < 0.01) independently from the presence of sildenafil, although at 24 h, the presence of sildenafil showed a trend towards improving the cell proliferation ( p = 0.0523) ( Figure 4 A,B).

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