Activation-induced cytidine deaminase localizes to G-quadruplex motifs at mutation hotspots in lymphoma.

The median percent BG4-positive malignant cells within a given tumor was 50%, and using ≥50% as a cutoff, there was a strong trend for a higher incidence of G4 formation in ABC-DLBCL in comparison to GCB-DLBCL (21/37, 57% versus 11/34, 32%; P = 0.06).

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We then analyzed each of the variables, AID mRNA, AID IHC and BG4 IHC, independently and observed only high AID mRNA levels identified DLBCL patients with worse OS and PFS, which maintained a trend toward significance with DLBCL subtype as a covariate for PFS only (Figure 6A ).

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