Role of opioid signaling in kidney damage during the development of salt-induced hypertension.

TRPC6 expression is elevated under hypertensive conditions and promotes pathological increase in Ca 2+ influx in response to κ-OR stimulation Western blot analysis revealed that TRPC6 expression was elevated in the hypertensive animal group ( Fig 6A and B ) and trended to be higher in the hypertensive opioid-treated group, although it did not reach statistical significance.

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